How to remove thumbs.db permanently?

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Google is your friend!

Regards,

If you do not like Thumbs.db, you can delete all these files without worrying about your operating system.
What you should do is to open “My Computer” then press F3 (Search in Winodws), then choose “All files and folders”, and in the “All or part of file name:” field type Thumbs.db.
Once the search finishes, select all Thumbs.db files right click on them, press the “Shift” button and choose delete. Then confirm the permanent deletion of the files.
1. Press the Start button
2. Select Settings -> Control panel
3. Select Folder options
4. Open the View tab
5. Mark the checkbox “Don Not Cache Thumbnails”
6. Click the OK
That’s it. Thumbs.db files will no longer appear on your computer.