I too have seen some of the same comments in various journals/trade mags. The malware war ("mal-war") is definitely in an uphill battle phase. The signature based products are in for a tough run for the foreseeable future. Blended attacks need "blended" solutions, eh?
The problem is maintaining a high level of system performance in conjunction with a high level of protection. One of the problems in addressing blended protection is the overall system performance drag and potential interaction issues between various protection options. After all, the reason for using a computer in the first place is efficiency and productivity in order to get more work done faster and thus leverage one's workplace time. If the system spends any significant portion of its time protecting itself then the usefulness of the system as a tool is reduced. A nasty conundrum - at best.
On my home-based machines, I am employing a hardware firewall (Netgear Wireless Router) + Windows SP2 firewall + Clamwin + Cyberhawk + SuperAntiSpyware. The hardware firewall provides the frontline barrier with zero system impact, the Windows firewall provides good solid in-bound protection with minimal system impact, Clamwin provides email scanning with no real-time system impact outside of email, Cyberhawk provides real-time behavioral/HIPS/Zero-Day protection against the nonexistent-signature attacks - with imperceptable system impact, and SAS provides manual scanning/cleaning for a considerable spectrum of non-virus malware. Admittedly, not the absolute most armor plated scheme - but it does leave system(s) much more responsive given that they are not the latest "bezillion Mbps octuple core trillameg RAM" systems

(that was fun)
But the point is, delivering productivity and protection on one's existing hardware base in today's "mal-war" environment.