Some malware now is injected into a program that is already in memory--such as your browser. It never resides in a file and thus is very hard to defend against. There is little an unsophisticated AV program like ClamWin or even Clam Sentinel can do to protect you against this. Therefore, until/unless ClamWin/Clam Sentinel can provide this protection, it is important to use an antivirus alongside them that does provide this protection. I do not know what free AVs provide this protection, but you might consider Security Essentials/Windows Defender or Panda Free.
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